case_id age gender country smoking_history smoke_age_start smoke_age_stop num_smoke_per_day num_pack_years_sm smoking_second_hand smoking_inferred alcohol_consum num_yrs_alc_con tumor_site_original tumor_site_curated tumor_focality tumor_size_cm histologic_type histologic_grade tumor_necrosis patho_staging_pt patho_staging_pn clinic_staging_dist_metas tumor_stage P16 HPV_inference NAT_pathology_review tumor_pathology_review ESTIMATE_stromal_score ESTIMATE_immune_score CD3_IHC_count stemness_score mutation_count neoAntigen_count chr_instability_idx integrated_subtype transcriptomic_subtype progression_free_survival progression_free_status overall_survival overall_free_status CAT CON BIN CAT CAT CON CON CON CON CAT BIN BIN CON CAT CAT BIN CON CAT ORD CAT ORD ORD ORD ORD CAT BIN CAT CAT CON CON CON CON CON CON CON CAT CAT CON BIN CON BIN C3L-00977 56 Male Russia "Current reformed smoker, years unknown" NA NA 20 NA Yes strong_evidence Lifelong non-drinker NA Floor of mouth Oral cavity Unifocal 1.2 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT1 pN1 cM0 Stage III Not Evaluated NO Soft Tissue No EPI% SCC 80% 6825.995755 7989.115925 1 0.953243158 106 0 2.003653988 Basal Mesenchymal 772 0 772 0 C3L-00987 61 Male Ukraine Current smoker: Includes daily and non-daily smokers 18 NA 20 43 Yes strong_evidence "Consumed alcohol in the past, but currently a non-drinker" 30 Tongue Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT2 pN1 cM0 Stage III Not Evaluated NO Soft Tissue No EPI;Normal No EPI% SCC 90%;SCC 90%;SCC 80%;SCC 70% 5999.793467 4772.409716 0 0.825329743 83 0 5.205611743 CIN Classical 429 0 429 0 C3L-00994 50 Male Ukraine Current reformed smoker within past 15 years 16 50 6 10.2 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 32 Tongue Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT2 pN0 cM0 Stage II Not Evaluated NO Normal EPI 10%;Normal EPI 10%% SCC 40%;SCC 70%;SCC 40%;SCC 75% 8924.036564 8176.233903 5 0.664581288 67 0 1.684474662 Immune Mesenchymal 133 1 202 1 C3L-00995 56 Male Ukraine "Current reformed smoker, more than 15 years" 25 56 20 31 Exposure to secondhand smoke history not available weak_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 31 Buccal mucosa Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT2 pN1 cM0 Stage III Not Evaluated NO Normal 15%;Normal 10%% SCC 90%;SCC 80%;SCC 40%;SCC 70% 8723.429667 8342.246345 70 0.539918433 64 0 1.340483316 Immune Mesenchymal -9 NA NA NA C3L-00997 47 Male Ukraine "Current reformed smoker, more than 15 years" 12 27 20 15 Yes strong_evidence Lifelong non-drinker NA Oropharynx Oropharynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT2 pN1 cM0 Stage II Not Evaluated NO Normal 10%% SCC 70%;SCC 70% 7025.911695 7445.251991 60 0.843765491 129 0 3.906369951 CIN Classical 442 0 442 0 C3L-00999 56 Male Russia Current smoker: Includes daily and non-daily smokers 20 NA 20 36 Yes weak_evidence Lifelong non-drinker NA Floor of mouth Oral cavity Unifocal 2.2 "Squamous cell carcinoma, conventional" G1 Well differentiated Present pT2 pN0 cM0 Stage II Not Evaluated NO Normal 10%% SCC 80%;SCC 70% 8510.704551 8210.549555 30 0.548977169 159 0 1.148834119 Immune Atypical 446 1 818 0 C3L-01138 62 Male Ukraine Current smoker: Includes daily and non-daily smokers 8 NA 20 54 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 6 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT4a pN1 cM0 Stage IV Not Evaluated NO Normal 10%% SCC 70% 6283.423855 6407.893478 10 0.890789746 187 1 3.924981694 Basal Classical 367 0 367 0 C3L-01237 57 Male Ukraine "Current reformed smoker, more than 15 years" 17 20 40 6 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN2 cM0 Stage IV Not Evaluated NO Normal 10%% SCC 80% 7175.667725 5720.287055 30 0.738328103 141 1 4.286489911 CIN Classical 20 0 20 0 C3L-02617 64 Male Bulgaria Current smoker: Includes daily and non-daily smokers 20 NA 30 66 Yes strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 20 Larynx Larynx Unifocal 6 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Present pT2 pNX Staging Incomplete Stage II Not Evaluated NO Normal 10%;Normal 15%;SCC 90%% SCC 90%;SCC 80%;SCC 80%;SCC 80%;SCC 80% 6346.815584 6958.57339 NA 0.906466019 470 1 4.744817564 CIN Classical 427 0 427 0 C3L-02621 68 Male Bulgaria Current smoker: Includes daily and non-daily smokers 38 NA 30 45 Yes strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 20 Larynx Larynx Multifocal 0.6 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Present pT1 pNX Staging Incomplete Stage I Unknown NO Normal 10%;Normal 10%;Normal 10%% SCC 70%;SCC 70%;SCC 70%;SCC 70%;SCC 65% 6806.384264 8039.787184 NA 0.754949822 358 0 1.774520975 CIN Atypical 314 0 314 0 C3L-02651 81 Male Bulgaria Current smoker: Includes daily and non-daily smokers 29 NA 30 78 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 2.5 Keratinizing Squamous Cell Carcinoma G2 Moderately differentiated Present pT2 pNX cMX Stage II Not Evaluated NO Normal 40%;Normal 20%;Normal 15%% SCC 70%;SCC 70%;SCC 70%;SCC 70%;SCC 70% 7397.640049 8476.382275 NA 0.6098734 402 0 2.000132392 NA Mesenchymal 291 0 291 0 C3L-03378 54 Male Russia Current smoker: Includes daily and non-daily smokers 20 NA 20 34 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Oral cavity Oral cavity Unifocal 1.8 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pN2c cM0 Stage IV Not Evaluated NO Normal 15%% SCC (PD) 70% 6878.201534 6924.419568 60 0.835631289 211 0 3.943512409 CIN Classical 370 0 370 0 C3L-04025 69 Male Bulgaria Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA No or minimal exposure to secondhand smoke weak_evidence NA NA Buccal mucosa Oral cavity Unifocal 1.5 NA G2 Moderately differentiated Not identified pT1b pNX NA Stage I NA NO SCC 70%;Normal 10%;Normal 30%% SCC 70%;WDSCC 65%;WDSCC 70%;Verrucous Non-Invasive 40%;WDSCC 70% 7562.669184 7805.771365 NA 0.519337914 30 0 0.379356904 Immune Mesenchymal 470 0 470 0 C3L-04354 60 Male Bulgaria Current smoker: Includes daily and non-daily smokers 30 NA 6 9 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 2 Non-Keratinized Squamous Cell Carcinoma G3 Poorly differentiated Present pT2 pNX cMX Stage II Not Evaluated NO Normal 20%;Normal No EPI;Normal 5%% SCC 75%;SCC 50%;SCC 55%;SCC 70%;SCC 75% 7228.703512 8055.848268 NA 0.618746239 180 0 3.70515534 CIN Atypical 408 0 408 0 C3L-04791 81 Male Bulgaria Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA No or minimal exposure to secondhand smoke weak_evidence Lifelong non-drinker NA Larynx Larynx Unifocal 3 Keratinizing Squamous Cell Carcinoma G2 Moderately differentiated Present pT1 pNX cMX Stage I Not Evaluated NO Normal Thyroid;Normal Thyroid;Normal No EPI% SCC 70%;SCC 75%;SCC 75%;SCC 70%;SCC 65% 6837.579096 7804.981646 NA 0.648402377 478 0 1.62512892 Immune Mesenchymal 273 0 273 0 C3L-04844 61 Female TSS did not collect Current smoker: Includes daily and non-daily smokers 21 NA NA NA Exposure to secondhand smoke history not available weak_evidence NA NA Tonsil Oropharynx Unifocal 6 NA G2 Moderately differentiated Not identified pT4a pN3 NA Stage IV NA NO Normal 70$ EPI% SCC 75%;SCC 70% 5714.862795 5923.495615 40 0.776764448 306 1 5.332853107 Basal Classical 290 0 290 0 C3L-04849 63 Male TSS did not collect Current smoker: Includes daily and non-daily smokers 18 NA NA NA Exposure to secondhand smoke history not available strong_evidence NA NA Floor of mouth Oral cavity Unifocal 4.7 NA G2 Moderately differentiated Present pT4a pN3 NA Stage IV NA NO Hyperplasia 70%% SCC 70%;SCC 75% 5757.546725 5841.490604 60 0.914700396 133 0 3.88309123 Basal Basal 356 0 356 0 C3N-00204 63 Female Bulgaria Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Lifelong non-drinker NA Larynx Larynx Unifocal 3.2 Adenosquamous carcinoma G3 Poorly differentiated Not identified pT3 pN1 cM0 Stage III Not Evaluated NO Normal 15%;Normal 5%% SCC 80%;PDSCC 80%;PDSCC 70%;PDSCC 75% 4141.503954 5229.928241 60 0.953230425 920 0 5.114648357 CIN Atypical 175 1 175 1 C3N-00295 53 Female Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 2.2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pNX cM0 Stage III Negative NO Normal 40%% SCC 40%;SCC 70%;SCC 65%;SCC 10% 4752.639319 4989.340444 NA 0.736752931 319 0 1.361230029 NA Atypical 1346 0 1346 0 C3N-00297 69 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Negative NO Normal no EPI% SCC 80%;SCC 70%;SCC 80%;SCC 80% 5822.516855 6936.01723 NA 0.541769935 125 0 1.941711169 Basal Basal 1358 0 1358 0 C3N-00299 54 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Alcohol consumption history not available NA Lip Lip Unifocal 3.1 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Negative NO Normal 0% EPI% SCC 80%;SCC 80%;C3N-00299-23;SCC 65% 5342.360428 8009.515355 NA 0.848396164 1065 0 1.157970806 Basal Basal 294 1 294 1 C3N-00306 50 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN0 cM0 Stage III Negative NO Normal 20% EPI% SCC 50%;SCC 65%;SCC 65%;SCC 45% 6485.079143 7685.055639 NA 0.567681993 128 0 1.766122221 Immune Atypical 973 0 973 0 C3N-00307 70 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Not identified pT4a pNX cM0 Stage IV Negative NO Normal 40%% SCC 70%;SCC 70%;SCC 70%;SCC 50% 7021.274977 7008.902307 NA 0.537980522 104 0 2.145210328 CIN Mesenchymal 199 1 199 1 C3N-00498 63 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Oral cavity Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN1 cM0 Stage III Positive (>70% nuclear and cytoplasmic staining) NO Normal 15%% SCC 45%;SCC 75%;SCC 75%;SCC 60% 5288.872044 4377.867323 NA 0.790722164 168 0 4.003498977 CIN Classical 1180 0 1180 0 C3N-00519 67 Male Poland "Current reformed smoker, more than 15 years" 27 67 20 40 Exposure to secondhand smoke history not available weak_evidence "Consumed alcohol in the past, but currently a non-drinker" 5 Larynx Larynx Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Negative NO Normal 15%% SCC 70%;SCC 70%;SCC 70%;SCC 70% 7349.981429 8246.069477 NA 0.601852135 177 0 1.020476094 Immune Atypical 638 0 638 0 C3N-00822 53 Female Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN0 cM0 Stage III Negative NO SCC 75%% SCCPD 80%;SCC 75% 4080.16184 4864.02235 50 0.928850145 87 0 3.849534933 CIN Classical 978 1 978 1 C3N-00825 53 Male Poland Current smoker: Includes daily and non-daily smokers 30 NA 22 25.3 Exposure to secondhand smoke history not available weak_evidence Alcohol consumption history not available NA Tongue Oral cavity Multifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Negative NO Muscle 0%% SCC 55%;SCC 70% 8446.53344 8615.897442 90 0.709392947 55 0 1.350090157 Immune Mesenchymal 330 0 330 0 C3N-00828 67 Male Poland "Current reformed smoker, more than 15 years" 16 66 20 50 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pNX cM0 Stage II Negative NO Normal 0%% SCC 70%;SCC 70%;SCC 60%;SCC 40% 5428.79908 6486.859053 NA 0.736569263 326 0 2.377393605 CIN Atypical 951 1 951 1 C3N-00829 53 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Tongue Oral cavity Unifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN2b cM0 Stage IV Negative NO Normal 20%% SCC 5%;SCC 10%;SCC 50%;SCC 45% 5642.230086 5786.945507 NA 0.785402648 173 0 3.855637501 CIN Classical 448 1 958 1 C3N-00846 67 Male Ukraine Current smoker: Includes daily and non-daily smokers 37 NA 10 15 Exposure to secondhand smoke history not available weak_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 2 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT1 pNX cM0 Stage I Negative NO Normal 5%% SCC 40%;SCC 45%;SCC 40% 8456.142513 9176.55781 NA 0.444508155 71 0 0.716663308 Immune Mesenchymal 615 1 644 0 C3N-00857 64 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN1 cM0 Stage IV Not Evaluated NO Normal 25%% SCC 60%;SCC 60% 5797.846142 4785.847019 1 0.862813515 175 0 7.021957997 CIN Classical 463 0 463 0 C3N-00871 58 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Oral cavity Oral cavity Unifocal 5.2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN2b cM0 Stage IV Not Evaluated NO Normal 0%% SCC 70%;SCC 75% 6278.855658 5085.878714 5 0.729252757 140 0 4.903849277 Basal Classical 415 1 415 1 C3N-01337 52 Male Poland Current smoker: Includes daily and non-daily smokers 30 NA 12 13.2 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 5 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT4 pN2b cM0 Stage IV Negative NO Normal 15%% SCC 80%;SCC 75% 5650.929868 7269.184407 10 0.768039988 133 0 1.972568298 Basal Atypical 616 0 616 0 C3N-01338 50 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN1 cM0 Stage III Negative NO Normal Cartilage% SCC 75%;SCC 75% 6117.170351 6477.301118 20 0.982769201 265 0 2.74001252 Basal Classical 492 1 574 0 C3N-01339 68 Female Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3.4 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Present pT4 pN1 cM0 Stage IV Not Evaluated NO SCC 70%% SCC 75%;SCC 70% 2933.655697 3813.652536 10 0.623259258 234 1 7.297807575 CIN Classical 215 1 215 1 C3N-01340 72 Male Poland "Current reformed smoker, more than 15 years" Unknown Unknown Unknown NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN0 cM0 Stage IV Not Evaluated NO Normal 15%% SCC 70%;SCC 70% 7441.043447 7793.863113 40 0.628752325 91 1 2.118216889 NA Atypical 1009 0 1009 0 C3N-01620 56 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 4.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN0 cM0 Stage III Negative NO Normal 20%% SCC 10%;SCC 60% 7332.918086 7128.615543 10 0.675434802 163 1 2.738195358 Basal Mesenchymal 710 0 710 0 C3N-01645 71 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN0 cM0 Stage III Negative NO Normal 20%% SCC 75%;SCC 70% 7001.081675 8716.71833 50 0.856966154 100 0 1.783471871 NA Mesenchymal 374 1 584 0 C3N-01752 73 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Floor of mouth Oral cavity Unifocal 5.6 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN0 cM0 Stage IV Not Evaluated NO NA WDSCC 65%;WDSCC 70% 5441.75976 4353.059497 1 0.967646007 127 0 5.621177931 Basal Basal 668 0 668 0 C3N-01754 64 Male Poland Current reformed smoker within past 15 years 22 63 20 41 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 4.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT3 pN0 cM0 Stage III Not Evaluated NO Normal 50%% SCC 20%;SCC 70%;SCC 70%;SCC 40% 6759.178398 6021.776653 10 0.839918856 104 0 4.158945639 Basal Basal 994 0 994 0 C3N-01755 68 Male Poland "Current reformed smoker, years unknown" NA NA 20 NA Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 PN1 cM0 Stage III Not Evaluated NO NA SCC 40%;SCC 75%;SCC 75% 6898.079644 6962.033648 20 0.68876914 110 0 4.512636233 CIN Mesenchymal 987 0 987 0 C3N-01756 62 Male Poland Current smoker: Includes daily and non-daily smokers 17 NA 10 22.5 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Hypopharynx Unifocal 4.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN2c cM0 Stage IV Not Evaluated NO Normal 20%% SCC 70% 5657.98446 4670.155568 20 0.878652596 100 1 4.95775001 CIN Classical 1035 0 1035 0 C3N-01757 64 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 2.7 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pNx cM0 Stage II Not Evaluated NO Normal 40%% SCC 40%;Poor Quality 70%;Poor Quality 70%;SCC 70% 6179.545402 7014.534802 50 0.790684392 153 0 1.969241618 Basal Basal 1058 0 1058 0 C3N-01758 59 Male Poland Current reformed smoker within past 15 years 19 59 15 30 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pN1 cM0 Stage IV Not Evaluated NO Normal 10%% SCC 75%;SCC 70%;SCC 75% 8044.356402 7692.143579 60 0.606988683 71 0 2.491776581 Basal Mesenchymal 485 0 485 0 C3N-01858 62 Male Poland Current reformed smoker within past 15 years 21 62 30 61.5 Exposure to secondhand smoke history not available weak_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 15 Larynx Larynx Unifocal 3.2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN3b cM0 Stage IV Not Evaluated NO Normal 20%% SCC 60%;SCC 75% 6267.242797 7198.497771 50 0.901155495 1349 4 0.944560823 NA Classical 200 1 598 0 C3N-01859 67 Male Poland Current reformed smoker within past 15 years 17 57 20 40 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 3.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pN2c cM0 Stage IV Not Evaluated NO Normal 30%% SCC 70% 6152.014132 8019.669666 60 0.817627441 239 1 4.166383438 CIN Atypical 76 0 76 0 C3N-01943 63 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN3a cM0 Stage IV Not Evaluated NO Normal 60%% SCC 70%;PDSCC 75% 4803.753271 7256.040173 80 0.872400321 131 1 2.504731762 CIN Atypical 659 0 659 0 C3N-01944 65 Male Poland Current smoker: Includes daily and non-daily smokers 20 NA 20 45 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 3.5 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Present pT4a pN1 cM0 Stage IV Not Evaluated NO Normal 10%% SCC 50% 7719.467126 7379.857472 40 0.668452661 106 0 2.629925627 Basal Mesenchymal 558 1 610 0 C3N-01945 61 Male Poland "Current reformed smoker, more than 15 years" Unknown Unknown 20 NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN1 cM0 Stage III Not Evaluated NO Normal 1%% Verrucous Non-Invasive 75%;SCC 70% 6931.64948 6694.529778 30 0.801326397 96 0 2.049894861 CIN Classical 20 0 20 0 C3N-01946 64 Male Poland Current reformed smoker within past 15 years Unknown Unknown Unknown NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Larynx Larynx Unifocal 1.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Not Evaluated NO Normal 60%% SCC 90% 7320.801741 9805.370561 70 0.66500437 1273 3 1.277888037 Immune Mesenchymal 217 0 217 0 C3N-01947 49 Male Poland Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Unifocal 5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN2b cM0 Stage IV Not Evaluated NO Normal 50%% SCC 90% 8369.540985 9086.657983 80 0.599903474 76 0 1.833096957 Immune Mesenchymal 401 0 401 0 C3N-01948 55 Female Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Alcohol consumption history not available NA Tongue Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN2b cM0 Stage IV Not Evaluated NO Normal 5%% SCC 65%;SCC 70% 7706.958045 9307.146827 80 0.629910425 66 0 0.915735253 Immune Atypical 422 0 422 0 C3N-02275 69 Male Poland Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Alcohol consumption history not available NA Larynx Larynx Unifocal 3.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN0 cM0 Stage IV Not Evaluated NO Normal 10%% SCC 50%;SCC 70% 6171.891354 8593.664692 50 0.749940074 747 5 1.742670537 Basal Mesenchymal 617 0 617 0 C3N-02279 59 Male Poland Current reformed smoker within past 15 years 20 59 20 39 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT3 pN0 cM0 Stage III Not Evaluated NO Normal 10%% SCC 50% 6815.19623 7399.477079 70 0.835648725 180 0 2.600950726 Basal Basal 414 0 414 0 C3N-02333 61 Male Ukraine Current reformed smoker within past 15 years Unknown 59 20 NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pNX cM0 Stage IV Negative NO Normal 5%% SCC 85%;SCC 85%;SCC 75% 7348.023786 9022.349073 50 0.526531556 345 0 0.623878945 Immune Mesenchymal 735 0 735 0 C3N-02694 57 Male Poland "Current reformed smoker, years unknown" NA NA 15 NA No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 2.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN2b cM0 Stage IV Not Evaluated NO NA SCC 85%;SCC 50% 8945.001701 9361.656935 NA 0.515325924 80 0 1.445698816 Immune Mesenchymal 239 0 239 0 C3N-02695 45 Male Poland Current smoker: Includes daily and non-daily smokers 17 NA 12 16.8 No or minimal exposure to secondhand smoke weak_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Multifocal 5 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT3 pN0 cM0 Stage III Not Evaluated NO Normal 5%% SCC 80%;SCC 80% 5937.036833 7022.660147 NA 0.755947066 87 0 2.044582098 Basal Basal 611 0 611 0 C3N-02700 80 Female Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Lip Lip Unifocal 3.5 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT2 pNX cM0 Stage II Positive (>70% nuclear and cytoplasmic staining) NO Normal 5%% SCC 80%;SCC 70%;SCC 80% 5691.04835 8128.32296 40 0.764721737 1372 2 2.230346416 Basal Basal 5 0 5 0 C3N-02713 64 Male Ukraine Current smoker: Includes daily and non-daily smokers 19 NA 20 45 Exposure to secondhand smoke history not available strong_evidence Lifelong non-drinker NA Larynx Larynx Unifocal 3.3 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Present pT3 pN2 cM0 Stage IV Not Evaluated NO Normal 10%% SCC 70%;SCC 80%;PDSCC 80% 5396.144947 5220.095945 60 0.797822192 638 0 5.22744393 CIN Classical 744 0 744 0 C3N-02714 23 Male Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Tongue Oral cavity Unifocal 2.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT2 pNX cM0 Stage II Positive (>70% nuclear and cytoplasmic staining) NO Normal 15%% PDSCC 70%;SCC 25%;SCC 75% 7581.433954 8894.705175 80 0.612150111 54 0 0.969092228 Immune Mesenchymal 907 0 907 0 C3N-02716 76 Male Ukraine Current smoker: Includes daily and non-daily smokers Unknown NA Unknown NA Exposure to secondhand smoke history not available weak_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Lip Lip Unifocal 1.2 "Squamous cell carcinoma, conventional" G1 Well differentiated Present pT1 pNX cM0 Stage I Positive (>70% nuclear and cytoplasmic staining) NO NA SCC 70%;SCC 45% 7083.32021 7778.97507 40 0.600350747 1270 1 0.10565008 Immune Atypical 258 0 258 0 C3N-02727 49 Male Ukraine Current smoker: Includes daily and non-daily smokers Unknown NA 20 NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 3.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pNX cM0 Stage IV Negative NO Normal Cartilage 0%% SCC 60%;SCC 70%;SCC 90% 8801.307424 9307.036194 60 0.471334213 33 0 1.154934045 Immune Mesenchymal 693 0 693 0 C3N-02730 40 Male China Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Tongue Oral cavity Unifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT1 pN1 cM0 Stage III Not Evaluated NO Normal 5%% SCC 75%;SCC 75% 8943.570062 9868.225196 NA 0.55895911 18 1 0.839975841 Immune Mesenchymal 365 0 365 0 C3N-02925 68 Female China Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Tongue Oral cavity Unifocal 4.2 Keratinizing squamous cell carcinoma G2 Moderately differentiated Not identified pT3 pN2b cM0 Stage IV Not Evaluated NO Normal 0%% SCC 85%;SCC 70% 7089.288448 9904.398057 NA 0.645009581 36 0 1.27973286 Immune Basal 770 0 770 0 C3N-03008 65 Female Poland Current smoker: Includes daily and non-daily smokers 20 NA 10 22.5 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 5 Floor of mouth Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN2c cM0 Stage IV Not Evaluated NO Normal 40%% SCC 70% 7532.452338 6864.752029 5 0.809266623 156 0 3.786564764 Basal Mesenchymal 158 1 158 1 C3N-03009 58 Male Poland Current smoker: Includes daily and non-daily smokers 16 NA 15 31.5 Yes strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women Unknown Floor of mouth Oral cavity Unifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT1 pN0 cM0 Stage I Not Evaluated NO Normal 35%% SCC 75%;SCC sub 5% 6797.453417 5131.34755 60 0.836561377 129 0 5.102849891 CIN Classical 655 1 655 1 C3N-03011 62 Male Poland Current reformed smoker within past 15 years 22 60 20 38 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 2 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Not identified pT2 pN2b cM0 Stage IV Not Evaluated NO Normal 35%% SCC 80%;SCC 70%;SCC 75% 5274.918068 6830.57982 40 0.831950566 67 0 5.059420434 CIN Atypical 396 1 598 1 C3N-03012 71 Male Poland "Current reformed smoker, years unknown" NA NA 20 NA No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN0 cM0 Stage IV Unknown NO Normal 35%% Normal 35% 6716.016019 4492.50941 0 0.83083229 343 0 6.120724664 CIN Classical 273 0 273 0 C3N-03013 59 Male Poland Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pNx cM0 Stage II Not Evaluated NO Normal 10%% SCC 65% 8855.514614 8805.211906 50 0.526153678 67 0 0.965558836 Immune Atypical 688 0 688 0 C3N-03015 61 Male Poland Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Unifocal 1 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Not identified pT4a pN2b cM0 Stage IV Not Evaluated NO Normal 10%% SCC 75% 7041.91195 8271.449708 70 0.898778348 192 0 1.799040506 Basal Atypical 660 0 660 0 C3N-03027 65 Male Poland Current smoker: Includes daily and non-daily smokers 17 NA 20 48 No or minimal exposure to secondhand smoke weak_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 8 Floor of mouth Oral cavity Unifocal 1 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pNx cM0 Stage II Not Evaluated NO Normal 35%% SCC 75% 5566.75901 7101.798643 80 0.808283426 118 0 2.792754143 CIN Atypical NA 1 310 1 C3N-03028 59 Male Poland Current smoker: Includes daily and non-daily smokers 20 NA 20 39 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women Unknown Floor of mouth Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN2b cM0 Stage IV Not Evaluated NO Normal 35%% SCC 80% 7353.736545 7831.873692 30 0.79897701 95 0 3.720644062 Basal Mesenchymal 652 0 652 0 C3N-03042 67 Female United States Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence NA NA Oral cavity Oral cavity Unifocal 5.2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified T4a N3b M0 Stage IV Negative NO SCC 30%;SCC 20%% SCC 80%;SCC 75%;SCC 75%;SCC 75% 6460.922624 5907.724612 40 0.822779851 98 0 2.52459111 Basal Mesenchymal NA NA NA NA C3N-03045 77 Male United States Smoking history not available NA NA NA NA Exposure to secondhand smoke history not available strong_evidence NA NA Tongue Oral cavity Unifocal 2.2 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified T2 N1 m0 Stage III Negative NO Normal 10%% SCC 75% 4932.8686 6125.854309 10 0.919189035 123 0 3.496837442 Basal Basal NA NA NA NA C3N-03226 54 Male Ukraine Current smoker: Includes daily and non-daily smokers 19 NA 20 35 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN2b cM0 Stage IV Not Evaluated NO Normal 5%% SCC 80%;SCC 70%;SCC 70% 7725.028018 8410.581778 50 0.670113161 41 0 0.773082844 Immune Atypical 730 0 730 0 C3N-03433 76 Male Poland Current smoker: Includes daily and non-daily smokers 22 NA 15 40.5 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 2.4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Not Evaluated NO Normal% SCC 7 6426.336016 7166.765405 60 0.755758699 459 0 4.446428964 CIN Classical 645 0 645 0 C3N-03456 64 Male Poland Current smoker: Includes daily and non-daily smokers 23 NA 20 41 Yes strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women Unknown Floor of mouth Oral cavity Unifocal 7 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4 pN0 cM0 Stage IV Not Evaluated NO NA SCC 6 6439.29269 5545.333423 50 0.809361582 92 0 4.62246548 CIN Classical 677 0 677 0 C3N-03457 71 Male Poland Current reformed smoker within past 15 years 22 71 15 36.8 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Unifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Not Evaluated NO Normal% SCC 70 9627.987701 9020.741798 30 0.468432263 236 0 1.660450213 Immune Mesenchymal 695 0 695 0 C3N-03458 70 Male Poland Current smoker: Includes daily and non-daily smokers 25 NA NA NA Yes weak_evidence NA NA Floor of mouth Oral cavity Unifocal 2 NA G1 Well differentiated Not identified pT2 pN0 NA Stage II NA NO Normal% SCC 65 6027.079084 6746.609023 20 0.896479674 124 1 2.48177344 Basal Atypical 693 0 693 0 C3N-03487 53 Female Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Alveolar ridge Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pN0 cM0 Stage IV Not Evaluated NO Normal% SCC 8;SCC 80%;SCC 80% 8134.452066 9299.472289 90 0.577214475 81 0 0.935948973 Immune Mesenchymal 726 1 728 0 C3N-03488 64 Male Ukraine Current smoker: Includes daily and non-daily smokers 19 NA 20 45 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Other Hypopharynx Unifocal 5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT3 pNX cM0 Stage III Not Evaluated NO Normal 20%;SCC 75%% SCC 80%;SCC 35% 7020.822857 5614.264427 50 0.862958537 113 0 5.162604132 Basal Mesenchymal 706 0 706 0 C3N-03490 64 Male Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Lifelong non-drinker NA Base of tongue Oropharynx Unifocal 4.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pN0 cM0 Stage III Not Evaluated NO N 10%% SCC 70%;SCC 75%;SCC 80% 6984.498413 6145.297042 30 0.816379845 136 1 5.883949077 CIN Classical 634 0 634 0 C3N-03612 51 Male Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Oropharynx Oropharynx Unifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT3 pNX cM0 Stage III Not Evaluated NO N 10%% PDSCC 15%;SCC 35%;SCC 65% 5983.808904 10678.10984 60 0.442356796 1 0 0.099793387 Immune Atypical 697 0 697 0 C3N-03619 59 Male Ukraine Current smoker: Includes daily and non-daily smokers 24 NA 20 35 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT2 pN0 cM0 Stage II Not Evaluated NO N 5%% SCC 60%;SCC 25%;SCC 70% 7000.525344 7267.440427 50 0.723910132 90 0 2.605347937 NA Atypical 97 0 97 0 C3N-03620 61 Male Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Tongue Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pNX cM0 Stage II Not Evaluated NO N 5%% SCC 70%;PDSCC 10;SCC 10% 8784.023801 9562.408984 90 0.495209781 14 0 0.852501029 Immune Atypical 149 1 728 0 C3N-03664 58 Male Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Lifelong non-drinker NA Floor of mouth Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN2c cM0 Stage IV Not Evaluated NO N 5%% SCC 65%;SCC 80%;SCC 75% 6235.504976 5794.499567 20 0.942451279 165 1 5.701625616 Basal Atypical 733 0 733 0 C3N-03781 68 Male Poland "Current reformed smoker, more than 15 years" 28 50 20 22 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN0 cM0 Stage IV Not Evaluated NO N 20%% SCC 60% 7985.804043 7107.47205 70 0.659516899 193 0 2.438259882 NA Mesenchymal 756 0 756 0 C3N-03782 50 Female Poland Current smoker: Includes daily and non-daily smokers 20 NA 20 30 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT4a pN0 cM0 Stage IV Not Evaluated NO N 10%% SCC 65% 5188.792619 4993.8734 50 0.862910851 95 0 4.848709728 Basal Atypical 628 0 628 0 C3N-03783 67 Male Poland Current smoker: Includes daily and non-daily smokers 17 NA 20 50 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Alveolar ridge Oral cavity Unifocal 2 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT2 pN2b cM0 Stage IV Not Evaluated NO N lymphoid B% SCC 70% 8012.368622 8451.386202 80 0.747829853 123 1 2.665722706 NA Mesenchymal 721 1 739 0 C3N-03785 66 Male Poland Current smoker: Includes daily and non-daily smokers 20 NA 4 9.2 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Tongue Oral cavity Multifocal 1.2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT1 pNx cM0 Stage I Not Evaluated NO N 3%% SCC(PD) 60 3037.218187 4178.197713 1 0.892066902 153 0 7.401312096 CIN Atypical 658 0 658 0 C3N-03837 54 Male China Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Lip Lip Unifocal 4.5 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT3 pN0 cM0 Stage III Not Evaluated NO N 35%% SCC 80%;SCC 80% 6229.92831 8003.79671 NA 0.720749789 459 0 0.701179286 NA Basal 706 0 706 0 C3N-03841 59 Male China Current smoker: Includes daily and non-daily smokers 25 NA 20 34 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 30 Other Larynx Unifocal 3 "Squamous cell carcinoma, conventional" G3 Poorly differentiated Not identified pT3 pN1 cM0 Stage III Not Evaluated NO N 15%% SCC 75%;SCC 75% 7057.917607 9004.291325 NA 0.684330926 96 0 3.983637062 CIN Mesenchymal 105 1 753 1 C3N-03849 55 Male China Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Larynx Larynx Unifocal 7 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT4a pN2b cM0 Stage IV Not Evaluated NO N 15%% PDCasub 70%;SCC 25% 6188.218272 6250.864705 NA 0.861893118 118 0 3.41718751 CIN Atypical 265 1 335 0 C3N-03876 65 Male China "Current reformed smoker, more than 15 years" 22 44 20 22 Exposure to secondhand smoke history not available strong_evidence Alcohol consumption more than 2 drinks per day for men and more than 1 drink per day for women 20 Larynx Larynx Unifocal 2.5 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT3 pN2b cM0 Stage IV Unknown NO N 15%% PDCa 70%;SCC 80% 5555.585958 5729.003577 NA 1 151 0 5.496287379 Basal Classical 465 1 465 1 C3N-03878 52 Male China Current smoker: Includes daily and non-daily smokers 32 NA 10 10 Exposure to secondhand smoke history not available strong_evidence Lifelong non-drinker NA Larynx Larynx Unifocal 2 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT3 pN1 cM0 Stage III Not Evaluated NO N 10%% SCC 70%;SCC 80% 6917.552525 6868.706676 NA 0.65847816 80 0 3.001682564 CIN Classical 390 0 390 0 C3N-03888 58 Male Ukraine Current smoker: Includes daily and non-daily smokers 18 NA 20 40 Exposure to secondhand smoke history not available weak_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 2 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT3 pNX cM0 Stage III Not Evaluated NO N 20%% SCC 30%;PDCa 70%;SCC 40% 4789.748963 6802.39559 30 0.857808178 125 0 4.02272702 CIN Atypical 306 0 306 0 C3N-03889 53 Male Ukraine Current smoker: Includes daily and non-daily smokers 23 NA 20 30 Exposure to secondhand smoke history not available weak_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Alveolar ridge Oral cavity Unifocal 4 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pN0 cM0 Stage IV Not Evaluated NO N 10%% SCC 75%;SCC 80%;SCC 70% 7941.455222 7219.722156 20 0.596663601 91 0 2.438247167 Immune Mesenchymal 288 0 288 0 C3N-03928 60 Female Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Tongue Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G1 Well differentiated Present pT2 pN1 cM0 Stage III Not Evaluated NO N 15%% SCC 70%;SCC 40%;SCC 70% 7661.031806 9098.218537 50 0.625748343 61 0 1.844770846 Immune Basal 280 0 280 0 C3N-03933 70 Female Ukraine Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available weak_evidence Lifelong non-drinker NA Floor of mouth Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT2 pN1 cM0 Stage III Not Evaluated NO N 15%% SCC 50%;SCC 70%;SCC 75% 7146.623165 7900.354223 80 0.689933031 87 1 5.485436765 Basal Basal 396 0 396 0 C3N-04152 54 Male Armenia Lifelong non-smoker: Less than 100 cigarettes smoked in lifetime NA NA NA NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Oropharynx Oropharynx Unifocal 4.5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT4a pN2b cM0 Stage IV Not Evaluated NO N 5%% SCC PD 60%;PDSCC 75%;PDC 70% 5153.497308 4863.601322 70 0.94586735 80 0 6.512616496 CIN Atypical 297 0 297 0 C3N-04273 73 Male Poland Current reformed smoker within past 15 years 30 68 20 38 No or minimal exposure to secondhand smoke strong_evidence "Consumed alcohol in the past, but currently a non-drinker" Unknown Oropharynx Oropharynx Unifocal 2 Basaloid squamous cell carcinoma G2 Moderately differentiated Present pT2 pN2b cM0 Stage IV Not Evaluated NO N 0%% PDCa 75%;PDCa 65% 4786.757912 4495.994769 40 0.746277202 111 0 7.023214588 CIN Atypical 425 1 425 1 C3N-04275 61 Male Poland Current smoker: Includes daily and non-daily smokers 20 NA 20 41 Yes strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 2 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT2 pN0 cM0 Stage II Not Evaluated NO N 35%% SCC 70% 6635.873278 8210.346626 50 0.451905628 82 0 1.153900243 Immune Atypical 313 0 313 0 C3N-04276 68 Male Poland Current reformed smoker within past 15 years 16 65 15 36.8 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 5 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT4a pN0 cM0 Stage IV Not Evaluated NO N 10%% PDCa 70% 6821.83286 5143.929607 5 0.51276159 165 0 5.199257066 CIN Mesenchymal 283 0 283 0 C3N-04277 72 Male Poland Current smoker: Includes daily and non-daily smokers 25 NA 10 23.5 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 1 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT3 pNx cM0 Stage III Not Evaluated NO N 30%% SCC 75% 7772.142353 8589.873314 70 0.57517292 112 1 1.445849187 Immune Mesenchymal 436 0 436 0 C3N-04278 71 Male Poland Current reformed smoker within past 15 years 30 68 15 28.5 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 4 Basaloid squamous cell carcinoma G2 Moderately differentiated Not identified pT3 pNx cM0 Stage III Not Evaluated NO N 25%% PD 70% 6713.95651 7074.622965 90 0.831636557 289 0 4.498365323 CIN Classical 351 0 351 0 C3N-04279 65 Male Poland Current smoker: Includes daily and non-daily smokers 20 NA 15 33.8 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Floor of mouth Oral cavity Unifocal 3 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Not identified pT2 pN0 cM0 Stage II Not Evaluated NO N 20%% PDCa 70% 4913.19811 5469.762929 20 0.862528998 183 0 5.766583941 Basal Classical 310 0 310 0 C3N-04280 65 Male Poland Current reformed smoker within past 15 years 18 28 20 10 No or minimal exposure to secondhand smoke strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 4 "Squamous cell carcinoma, conventional" G1 Well differentiated Not identified pT2 pN0 cM0 Stage II Not Evaluated NO NA Veracan 80% 5615.887039 5361.231467 50 0.694324729 77 0 1.665145483 Basal Basal 232 0 232 0 C3N-04611 55 Male Ukraine Current smoker: Includes daily and non-daily smokers Unknown NA 20 NA Exposure to secondhand smoke history not available strong_evidence Alcohol consumption equal to or less than 2 drinks per day for men and 1 drink or less per day for women NA Larynx Larynx Unifocal 6 "Squamous cell carcinoma, conventional" G2 Moderately differentiated Present pT3 pNX cM0 Stage III Not Evaluated NO N 5%% PDCa 70%;PDCa 70%;PDCa 80% 8445.538834 8745.826501 90 0.680310507 107 0 1.701306377 Immune Mesenchymal NA NA NA NA